The Senescence-Associated Secretory Phenotype (SASP) is a hallmark of cellular senescence, characterized by the robust secretion of bioactive molecules such as pro-inflammatory cytokines, chemokines, matrix metalloproteinases, and growth factors by senescent cells. Through paracrine and autocrine mechanisms, the SASP induces chronic low-grade inflammation in local and systemic microenvironments ...

Fibular (peroneal) neuropathy is the most common mononeuropathy of the lower limb and a frequent cause of foot drop, most often occurring at the fibular head. While electrodiagnostic studies remain the reference standard for functional assessment, Magnetic Resonance Neurography (MRN) plays an important role in localizing ...

Immunity is a basic feature of life. Some immunological mechanisms are not completely understood. Burnet’s Clonal selection Theory barely explains how a limited number of immune cell clones can ensure immunity to numerically superior antigenic determinants, and how strict timing of immune reactions can be achieved.

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is transmitted between humans through aerosols. It is assumed that protective face masks prevent the spread of SARS-CoV-2. However, face masks vary in their type and efficacy and the reported effectiveness of face masks to prevent the spread of SARS-CoV-2 has varied although the reason for this variation is not well understood.

Linitis plastica is a descriptive term usually referring to the appearance of the stomach that is reminiscent of an old leather water bottle. A 55-year-old gentleman was evaluated for dyspepsia. He was diagnosed to have Biopsy proven adenocarcinoma of the stomach....

Type 2 Diabetes Mellitus (T2DM) represents a global health challenge. While Continuous Energy Restriction (CER) is the standard dietary intervention, it is often hindered by poor long term-adherence. Intermittent-Fasting (IF) and Time-Restricted Eating (TRE), a subtype of Intermittent-Fasting regimen and an intervention that tries to align food intake with circadian rhythm of the pancreatic beta cells, has emerged as an alternative. ...

In nematodes, caspase activation can cause apoptotic cell death during developmental cell death, which is then followed by adjacent cells phagocytosing the dead cell. Phosphatidylserine exposure on the cell surface is linked to apoptotic cell death and can serve as an eat-me signal for phagocytosis. However, for certain nematode cells...

Half a century ago, the womb was a “black box” - a space of mystery where fetal intervention was largely reactive and often too late. In the field of gynecology, many procedures remained invasive, with recovery times measured in weeks and outcomes clouded by a lack of gender-specific data.

Chronic wounds, including venous ulcers and diabetic foot ulcers, impose significant clinical and economic burdens globally. Compression therapy is a cornerstone intervention, yet its optimal application timing and management strategies lack standardized guidelines.

Chronic wounds, including venous ulcers and diabetic foot ulcers, impose significant clinical and economic burdens globally. Compression therapy is a cornerstone intervention, yet its optimal application timing and management strategies lack standardized guidelines.